CG/2D blends can work, if they don't do the whole LOOK CG YAY. I think Treasure Planet pulled it off beautifully with Silver (not so much with the backgrounds though)
I used to be all '2D is bestest, down with CG' over my animation, and while I prefer working on 2D myself, now whatever I watch doesn't bother me as long as it's done nicely. Because bad animation hurts everybody.